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000-152 - System x Technical Principles V10 - Dump Information

Vendor Name : IBM
Exam Code : 000-152
Exam Name : System x Technical Principles V10
Questions and Answers : 46 Q & A
Updated On : October 15, 2018
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IBM 000-152 Exam (System x Technical Principles V10) Detailed Information

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000-152 System x Technical Principles V10

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000-152 exam Dumps Source : System x Technical Principles V10

Test Code : 000-152
Test Name : System x Technical Principles V10
Vendor Name : IBM
Q&A : 46 Real Questions

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IBM IBM System x Technical

IBM food have confidence Expands Blockchain network to Foster a Safer, extra clear and efficient international food system | killexams.com Real Questions and Pass4sure dumps

(MENAFN Editorial) iCrowdNewswire - Oct 14, 2018

IBM (NYSE:IBM) today introduced starting to be adoption of its meals supply chain community, IBM food have confidence. The blockchain-based cloud network presents taking part marketers, suppliers, growers and food industry suppliers with data from throughout the food ecosystem to permit superior traceability, transparency and efficiency.

The community is now often obtainable after 18 months in testing, throughout which millions of individual food products had been tracked by dealers and suppliers.

The ecosystem of community members continues to grow, and nowadays, main global retailer Carrefour announced they're going to use the IBM food have confidence blockchain community to enhance their food excellence moves. As one of the vital world's main retailers with greater than 12,000 stores in 33 nations, Carrefour outlets will originally use the solution to highlight buyers' self belief in a few Carrefour-branded products. As a commitment of the retailer's Act for Foodprogram, the answer is anticipated to extend to all Carrefour manufacturers international through 2022.

"Being a founding member of the IBM meals believe platform is a fine probability for Carrefourto accelerateand widen the mixing of blockchain technology to our products with a purpose to give our consumers with safe and undoubted traceability," referred to Laurent Vallée, accepted secretary of Carrefour. "this is a decisive step in the roll-out of Act for meals, our international program of concrete initiatives in want of the meals transition."

using blockchain for depended on transactions, meals can be immediately traced returned to its source in as little as a number of seconds as a substitute of days or weeks. in contrast to natural databases, the attributes of blockchain and the ability to permission facts, allows community individuals to benefit a brand new level of relied on guidance. Transactions are recommended via multiple events, leading to an immutable single edition of the actuality.

"The currency of have confidence these days is transparency and attaining it within the area of food security occurs when responsibility is shared,"Bridgetvan Kralingen,senior vice president,IBMGlobal Industries, purchasers, structures andBlockchain. "That collaborative approach is how the participants of IBM food have confidence have shown blockchain can support transparency and pressure meaningful enhancements to meals traceability. in the end that offers business benefits for contributors and a much better and safer product for patrons."

A growing EcosystemThe individuals of IBM food have confidence have helped build a powerful international enterprise answer this is interoperable and constructed on open requirements. this is designed to allow organizations in the meals business to run their companies more conveniently and provide safer meals at lower charges.

in addition to Carrefour, corporations becoming a member of IBM food have faith include:

  • leading cooperative Topco associates, LLC, representing forty nine contributors, attaining over 15,000 shops and sixty five million weekly shoppers;
  • Retailer-owned cooperative Wakefern, representing 50 member organizations and 349 stores;
  • Suppliers together with BeefChain, Dennick Fruit supply, Scoular andSmithfield.
  • "Blockchain holds the potential to assist us be greater clear and radically change how the food industry works through rushing up investigations into contaminated meals, authenticating the beginning of meals, and offering insights about the circumstances and pathway the meals traveled to establish opportunities to maximize shelf life and cut back losses because of spoilage," saidEd Treacy, vice chairman of supply Chain Efficiencies at the Produce marketing affiliation.

    These newest individuals be part of a circulate it's accelerating amongst sellers and suppliers. as an example, Walmart, an early proponent of blockchain expertise,lately announcedthat it will begin requiring its leafy green suppliers to trap digital, conclusion-to-end traceability adventure assistance the usage of IBM meals have confidence.

    past the aim of constructing food safer, the IBM meals believe community and accompanying solutions have expanded to focal point on optimizing the food give. This contains producing insights on product freshness, decreasing waste and making the give chain more collaborative and transparent.

    IBM is working with services and expertise suppliers to make contributions essential provide chain, provenance, checking out and sensor records to the blockchain ecosystem. via a library of IBM food have confidence APIs, hardware, utility and know-how companies can write transaction statistics directly onto the blockchain network to supply advantageous insights.

  • 3Mis working with IBM to allow its food safeguard diagnostic device to talk with the blockchain community, should a meals brand choose to permit this capability.
  • Centricity, a grower-owned enterprise, makes it effortless to assemble, give protection to and share agronomic and compliance statistics between programs and trading companions, even with formats.
  • Trellis Frameworkis an open-source meals trade usual and API service that allows true-time connections between businesses and machines with full automation that scales.
  • Emersonis leveraging its superior cold chain technology to supply temperature-linked tips on in-transit, refrigerated cargo to improve shelf existence estimates and food freshness, enabling greater actionable facts for community participants.
  • "The vigor of IBM meals trust is in bringing collectively not handiest marketers and suppliers but also the leisure of the ecosystem touching our food deliver," saidNatalie Dyenson, vp, meals safeguard & high-quality, Dole. "as an example, Dole is working with Centricity, a grower-owned partner, to connect audit records to the blockchain by means of leveraging the Trellis framework as a standard for the produce trade, using existing codecs and methods. by means of simplifying on-farm and front-office reporting and placing facts on the blockchain, IBM meals trust has helped Dole free up the value of compliance facts throughout our suppliers and partners in a cost-beneficial approach."

    Governance for Shared a NetworkIBM meals have faith makes use of a decentralized model to allow assorted participating individuals of the food supply chain from growers to suppliers to retailers to share meals origin details, processing data and transport counsel on a permissioned blockchain community. each node on the blockchain is controlled with the aid of a separate entity, and all statistics on the blockchain is encrypted. The decentralized features of the network permit all parties to work collectively to make certain the statistics is relied on.

    As one of the largest and most energetic commercial enterprise blockchain networks in creation to this point, IBM meals trust individuals pioneered a complete governance mannequin for the community to assist be sure that the rights and counsel of all participants might be managed and guarded appropriately. The governance model ensures every member abides by the identical set of rules. agencies that add facts continue to own the statistics, and the facts owner is the only 1 that may provide permission for facts to be viewed or shared. crucial blockchain network management issues had been addressed, together with information entry, membership, interoperability and protection and hardware requirements, while featuring a consistent way to standardize data.

    regular AvailabilityAvailable these days globally, IBM food believe runs on the IBM Cloud and features commercial enterprise-type safety, reliability and scalability. The basis of the technology relies on Hyperledger textile, an open source blockchain framework hosted by the Linux basis. in addition, the network includes compatibility with the GS1 usual used through much of the food industry to make certain interoperability for traceability methods.

    contributors can opt for from three IBM food have faith software-as-a-provider modules with pricing that is scaled for small, medium and world firms, starting at$one hundred USDper month. Suppliers can make a contribution records to the network for gratis.

  • trace The hint module makes it possible for participants of a meals ecosystem to extra securely hint products in seconds to help mitigate move-infection, and reduce unfold of food-borne sickness and unnecessary waste a method that commonly takes weeks using different strategies.
  • Certifications The certifications module helps determine the provenance of digitized certificates, equivalent to biological or fair change. It additionally allows participants throughout the ecosystem to effectively load, manipulate and share food certifications digitally, rushing up certificates management through as much as 30 p.c.
  • information entry and entry The facts entry and entry module makes it possible for members to soundly add, entry and manage records on the blockchain.
  • IBM food trust is available as a subscription provider for contributors of the food ecosystem to join. For more counsel on availability, please visithere.

    About IBM Blockchain

    IBM is recognized as theleading commercial enterprise blockchain company. The enterprise's research, technical and company experts have damaged limitations in transaction processing speeds, developed probably the most advanced cryptography to comfortable transactions, and are contributing tens of millions of strains of open supply code to enhance blockchain for corporations. IBM is the chief in open-source blockchain solutions constructed for the commercial enterprise. on the grounds that 2016, IBM has worked with tons of of consumers across financial functions, supply chain, government, retail, digital rights management and healthcare to enforce blockchain functions, and operates a couple of networks operating are living and in creation. The cloud-primarily based IBM Blockchain Platform delivers the conclusion-to-end capabilities that valued clientele should right now prompt and efficiently enhance, function, govern and secure their own company networks. IBM is an early member of Hyperledger, an open supply collaborative effort created to advance cross-trade blockchain applied sciences. For more assistance about IBM Blockchain, visithttps://www.ibm.com/blockchain/or comply with us on Twitter at @ibmblockchain.

    Contact:Hannah Slocum, [email protected]

    Contact advice:

    Contact: Hannah Slocum, [email protected]

    MENAFN1410201800703403ID1097566645

    IBM Food Trust Expands Blockchain Network to Foster a Safer, More Transparent and Efficient Global Food System

    tons of of leading world firms install IBM Cloud deepest | killexams.com Real Questions and Pass4sure dumps

    to fulfill turning out to be demand, IBM advances on-prem private cloud with new Watson AI capabilities

    ARMONK, N.Y., Oct. eleven, 2018 /PRNewswire/ -- IBM (NYSE: IBM) has introduced that in under twelve months on account that the release of IBM Cloud inner most – an open supply expertise that brings cloud capabilities to corporations running on-premises IT methods – a whole bunch of main organisations international have became to the platform to aid modernize their operations. They encompass New Zealand Police, China's Fuyao group, Japan's Aflac coverage, Turkey's credit score bureau Kredi Kayıt Bürosu and Brazil's constancy countrywide counsel functions.

    IBM service provider logo. (PRNewsFoto/IBM agency) (PRNewsFoto/) (PRNewsfoto/IBM)

    extra

    constructing on this momentum, IBM is saying a slate of new superior elements for the on-premises inner most cloud platform, including the combination of potent AI capabilities reminiscent of IBM Watson Assistant and IBM Watson Speech-to-textual content, as well as guide for further public clouds, together with the IBM Cloud. The updates give clients with even more alternative and adaptability for their IT journeys, and, for the primary time, carry the vigor of IBM's Watson AI at the back of the business firewall.

    IBM is releasing particulars of over a dozen businesses which can be driving transformation with IBM Cloud private, together with:

  • New Zealand Police (NZP) is using the latest applied sciences to seriously change its operations and increase its capability to tackle crime and maintain the neighborhood protected. NZP is exploring how IBM Cloud inner most and Kubernetes containers can support to modernize its current methods in addition to rapidly launch new functions akin to a cell based communications gadget for its officers.
  • Fuyao community is China's biggest and most advanced manufacturer of automotive glass presenting Audi, Bentley, established Motors, Toyota and different suitable vehicle makers. to fulfill becoming demand, Fuyao has launched into a wise Manufacturing initiative and is the use of IBM Cloud deepest to aid integrate the management of business applications across its international manufacturing and enterprise operations, making certain the free circulation of guidance throughout the organization.
  • Aflac coverage, Aflac coverage, a leading company of clinical and melanoma assurance presenting insurance plan to 1 in 4 households in Japan, has signed an settlement with IBM to support simplify and automate its IT infrastructure. With IBM Cloud inner most, Aflac plans to boost the efficiency of its operations and pace up the construction of latest items and services.
  • Kredi Kayıt Bürosu (KKB) provides the country wide cloud infrastructure for Turkey's finance industry. closing 12 months KKB centered a brand new facts center in Ankara and is now the usage of IBM cloud inner most to support consolidate and localize the banking methods of over one hundred fifty participants including banks and different monetary features groups. With IBM Cloud private, KKB is capable of power innovation throughout its fiscal functions ecosystem while assembly the high standards for records safety and privateness.
  • Brazil's fidelity country wide tips services (FIS), a world leader in fee processing solutions for the fiscal trade, has adopted IBM Cloud deepest to assist streamline bank card chargebacks for its Brazilian operations. IBM Cloud private is helping FIS to orchestrate the a number of IT techniques involved in reconciling and checking of transaction chargebacks whereas meeting the stringent regulatory requirements of the business and assisting to stay away from fraud.
  • "The cloud has advanced in a really short time from being a method to cut prices to a platform for company transformation and innovation," noted Robin Hernandez, Director, IBM private Cloud offering administration. "Our IBM Cloud private affords shoppers a transition to cloud it really is designed to enable them to preserve their on-premises methods on which they nevertheless rely for a lot of mission-essential purposes and sensitive records sets."

    placing AI inside the EnterpriseToday IBM is advancing IBM Cloud private even additional, saying essential enhancements to the platform, starting from AI capabilities to extra public cloud guide. beginning nowadays, IBM Watson Speech-to-textual content is now attainable with the new IBM Cloud inner most version three.1, making it the first time the device is accessible in an on-premises atmosphere. With Watson Speech-to-textual content, clients can immediately transcribe and analyze audio from seven distinct languages.

    in addition, IBM Watson Assistant is now available on IBM Cloud deepest. The Watson Assistant platform helps builders and non-technical clients to create conversational AI solutions, from primary chatbots to complex enterprise grade options for client provider and greater.

    IBM also introduced nowadays that IBM Cloud deepest is now attainable on the IBM Public Cloud, to support customers to without difficulty move their business workloads from on-premises programs to the general public cloud with a view to create hybrid cloud environments.

    customer quote"IBM Cloud private is assisting us to establish an conclusion-to-conclusion digital platform so that you can underpin a smarter, extra agile, and more flexible corporate operating structure," spoke of Mr. Lebing Xia, vice chairman and CIO of the Fuyao community. "And via enabling us to connect with different cloud-primarily based functions like AI, Blockchain and IoT, we could be able to get even more company value from the cloud."

    Analyst quoteAccording to IDC's international Quarterly 2Q18 Cloud IT Infrastructure Tracker, September 2018, total global spending on cloud IT infrastructure is expected to total $sixty two.2 billion in 2018 with year-over-year increase of 31.1%. whereas public cloud datacenters will account for almost all of this spending, on-premises inner most clouds will account for nearly 20% of the overall cloud IT infrastructure market, turning out to be at 19.3% 12 months over 12 months in 2018. "agencies have various company and IT needs some of which are smartly served by using public cloud offerings and a few which aren't," mentioned Natalya Yezhkova, analysis Director, IDC. "On-premises inner most cloud is a magnificent choice for based companies that are searching for a gradual approach for reworking their corporation while holding handle of their IT infrastructure."

    Story Continues

    About IBM CloudWith $18.5B in annual cloud revenue, IBM is the world chief in commercial enterprise cloud with a platform designed to meet the evolving wants of company and society. relocating previous productivity and price advancements, the IBM Cloud is tuned for the AI and information demands which are driving authentic differentiation in brand new enterprise. IBM's deepest, public and hybrid offerings provide the world scale businesses should guide innovation throughout industries.

    constructed on open supply frameworks Docker containers and Cloud Foundry, and managed with the Kubernetes container structure, IBM Cloud inner most makes it possible for businesses to enhance cloud-native applications and also modernize on-premises purposes with the intention to installation them in both private cloud settings or the public cloud of their option.

    Media contacts:Jonathan BattyIBM Media family members (Europe)jjbatty@ibm.com

    Michael ZimmermanIBM Media members of the family (US)mrzimmerman@us.ibm.com

    Notes for journalists and editorsExamples of different leading global firms reworking with IBM Cloud private:

    CNH Industrial, ItalyCNH Industrial, a leader in the capital items sector operating in the agricultural and development machine, business automobiles, strong point vehicles and powertrain segments, has signed a multi-year cloud contract with IBM. during the deal it'll use IBM Cloud inner most and Watson artificial Intelligence to transform its business tactics - from manufacturing to deliver chain, revenue & marketing and monetary functions. IBM Cloud deepest will assist CNH Industrial to optimize its administration of commercial enterprise purposes whereas still benefitting from the safety of manage of its personal on-premises infrastructure. The agility and flexibility of ICP has the lengthy-term talents of generating improved efficiencies in application construction and will enable faster time to market for new inventive consumer services.

    Klirinski Interbankarski Sistemi ad Skopje (KIBS), Macedonia Klirinski Interbankarski Sistemi ad Skopje (KIBS), a Macedonia-based charge system operator owned with the aid of 12 banks is working with IBM to transform charge clearing strategies and guide quicker the integration of Macedonia's banking gadget with the eu. With IBM Cloud deepest KIBS should be in a position to consolidate and seriously change their existing materials into a "digital manufacturing facility" capable of growing and operating contemporary cloud-native functions on the fly. it is hoped that this transformation will in the reduction of time to market for brand new digital items from one-and-a-half years to just a number of months, while optimising working costs and supporting KIBS' compliance actions involving stringent banking laws.

    Sentient.io, SingaporeSentient.io, one in every of Singapore's leading artificial Intelligence companies, is working with IBM to convey on its mission to enrich everyday life by using making human and machine interactions greater herbal and pervasive.Sentient.io has chosen the IBM Cloud inner most as a platform to host Singapore's first AI-as-a-carrier (AaaS) platform to allow its shoppers to radically change and automate their groups with AI capabilities such as belief, knowing, self-gaining knowledge of and difficulty-fixing. using IBM Cloud private, Sentient.io will assist executive and business customers to fulfill strict facts protection and privateness requirements, modernize existing functions by moving them to the cloud, and without problems manipulate the lifecycle of their digital belongings.

    Ilmarinen, FinlandIlmarinen, the biggest deepest insurer in Finland liable for the pensions of over 1.1 million conclude citizens and more than EUR 45 billion in funding property, has shifted functions to IBM Cloud private to allow it to increase new digital capabilities while maximizing its present IT infrastructure. by way of putting its software development pipeline onto IBM Cloud private, Ilmarinen is in a position to enormously velocity up construction cycles and reduce infrastructure expenses, cutting the overall utility free up time from days to minutes. this is specifically crucial with extended force on the realm's pension techniques because of an getting older inhabitants.

    Techniker Krankenkasse (TK), GermanyGermany's largest statutory health insurance fund Techniker Krankenkasse (TK) is using IBM Cloud inner most for a new carrier known as TK-secure which gives shoppers with their health insurance statistics via their smartphone - in spite of time and site. IBM is already offering guidance as-a-provider to TK-protected's secure facts vault which consists of the encrypted fitness statistics of TK's coverage shoppers across Germany. by way of an open service platform, TK-protected is in a position to immediately and easily boost and launch new cost-brought features for insured persons, coverage agencies, carrier suppliers and hospitals.

    Mangalore institution, IndiaMangalore institution, one in all India's good public education institutions, will deliver new-age lessons in rising applied sciences via its affiliated faculties and is leveraging the power of IBM Cloud private to give a common platform that will also be accessed remotely by any student. IBM Cloud deepest will run on the institution's IBM energy servers as part of a finished answer which also comprises QRadar, MaaS360 and Cognos software. The answer could be integrated through Nihon communique solutions, an training delivery associate of IBM, which is responsible for the delivery of superior courses on cybersecurity and massive facts Analytics and provides high-performance systems for community and safety applications.

    SK Holdings C&C, Ltd., South KoreaSK Holdings C&C, a leading IT features company and IBM company companion in South Korea turned to IBM Cloud deepest to right away and simply package purposes as containers and re-factor them with IBM microservices. moreover, the business is leveraging the application to assist shoppers modernize their legacy applications and supply a comfy platform from which to run company essential utility across both public and private clouds, in a real multi-cloud architecture.

    Five9 Vietnam Corp., VietnamFive9 Vietnam is a fast-transforming into IT and cloud provider provider that provides its consumers with every thing from cellular and analytics utility development, to private and public cloud functions. The enterprise has been using IBM Cloud private on the grounds that April to design, develop, and equipment applications as containers for easy deployment on the public cloud. From there, their purchasers can tap into IBM microservices, equivalent to analytics, AI and blockchain, to prolong their functionality even additional.

    View customary content to download multimedia:http://www.prnewswire.com/news-releases/tons of-of-main-global-companies-install-ibm-cloud-private-300729130.html


    The Winds Are changing In Servers -- AI ends up in chance for IBM & vigour | killexams.com Real Questions and Pass4sure dumps

    IBM and the vigor structure excel at AIIBM

    There has by no means been a single processor architecture for server functions as a result of no two workloads are the identical. however, for the past decade, Intel has all but dominated the server market, shutting out AMD, the only other x86 server supplier, and leaving most effective HPC, mainframe, database and different specialized applications for other processor architectures. With the trade dealing with challenges as a result of a becoming listing of protection vulnerabilities from defective speculative execution implementations, altering workload requirements, slowing of Moore’s legislation, and inventive new processor architectures, server OEMs and customers are all looking at making alterations. lots of the new processor providers are specializing in specific segments to goal. IBM appears the most excellent placed to benefit from the colossal pastime in AI.

    apart from the changing technical and market dynamics, Intel has also stumbled in both manufacturing method and structure. they have got struggled to transition to the 14nm and 10nm technique nodes and now seem neatly behind Samsung and TSMC, the primary main foundry service providers, in transitioning to the 7nm technique node. moreover, Intel has purposely confined reminiscence bandwidth in its Xeon processors to promote two-socket servers over single-socket configurations. This has created a renewed opportunity for the IBM with its energy structure.

    by way of leveraging these main foundries, IBM has the flexibleness to leverage the optimum density and most not pricey procedure expertise. moreover, IBM has concentrated the design of the vigor structure on ordinary device efficiency and leveraging software, corresponding to PowerAI, for superior information flows. The area that is important in both AI training and inference is bandwidth to memory, to accelerators and to the community. IBM’s energy architecture not only helps more memory than competitive Xeon structures, however it also delivers about 10x the bandwidth to accelerators with NVLink. NVIDIA is the leader in AI accelerators with its Tesla line of GPU accelerators and vigor is the best processor architecture the use of NVIDIA’s NVLink interface at once within the processor itself which tremendously improves performance. moreover, the NVLink is coherent, which permits the GPUs to have direct access to the gadget reminiscence enabling gigantic AI fashions up to 2TB in dimension instead of being restricted to just the GPU reminiscence.

    whereas Intel Xeon’s are used as the host processor in many of the put in statistics core neural networks, consumers will see a improvement to leveraging accelerated structures with greater efficiency and bandwidth.

    The IBM AC922 vigor-based mostly platform that leverages Nvidia GPUs and NVLink for higher device bandwidthIBM

    despite the fact, the hardware is barely half the story. besides the hardware improvements, IBM additionally developed tools increasing the ability of open supply frameworks like TensorFlow and Caffe, in addition to offering a desktop-studying library referred to as Snap ML that additional reduces the working towards of new neural networks by using leveraging generalized linear models as opposed to ranging from scratch. most of the libraries are being developed especially for rising purposes like photo and video cognizance. In the use of the ImageNet dataset, IBM claims that may instruct neural networks up to 4 times quicker than a Xeon-based mostly system. With Caffe, IBM turned into capable of take the practicing of a neural community from hours all the way down to minutes whereas making it less difficult for statistics scientists to use greater intuitive tools in place of discovering to code.

    The IBM hardware and application vigour platform for AIIBM

    IBM's disbursed Deep learning (DDL) application for extended scaling efficiencyIBM

    IBM also developed dispensed Deep studying (DDL) utility that, along side the energy architecture, enables for better scaling of efficiency for large equipment configurations using multiple servers each and every with numerous GPUs, well-nigh enhancing the parallelization that may also be executed with giant workloads.  With DDL, IBM architected ninety five% efficiency with 256 NVIDIA GPUs in sixty four IBM vigour methods.

    an extra entertaining point of IBM is that it presents a range of systems for on-premises statistics facilities to the big cloud facts facilities, and even offers AI as a service with entry to its personal data core elements leveraging vigor.

    As workloads trade, server valued clientele are seeking greater alternatives to satisfy an increasing array of efficiency necessities by the becoming number of distinct workloads. within the case of AI, IBM has developed a niche in combination with its companion NVIDIA that gives a platform that presents the optimum efficiency in AI. moreover, IBM offers a full range of comprehensive systems and features that take lots of the technical challenges out of records science. TIRIAS analysis is evaluating each of the server processor architectures to peer how and the place they fit in the altering server environment. With different analysis in AI, akin to Watson, IBM seems to have discovered a strong place for the vigour platform.

    The creator and contributors of the TIRIAS analysis team of workers do not cling fairness positions in any of the corporations outlined. TIRIAS research tracks and consults for groups throughout the electronics ecosystem from semiconductors to programs and sensors to the cloud. individuals of the TIRIAS research team have consulted for IBM, Intel, and NVIDIA.


    000-152 System x Technical Principles V10

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    000-152 exam Dumps Source : System x Technical Principles V10

    Test Code : 000-152
    Test Name : System x Technical Principles V10
    Vendor Name : IBM
    Q&A : 46 Real Questions

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    System x Technical Principles V10

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    How IBM, Google and Amazon Innovate Differently | killexams.com real questions and Pass4sure dumps

    Every organization strives to innovate, but few succeed consistently over time. That's why so many once dominant companies hit a peak and then decline. A recent study estimates that 50% of the current S&P 500 will be replaced over the next ten years. Success is supposed to breed success, but it often breeds failure. 

    Yet IBM, Google and Amazon have been able to buck this trend. While most companies are lucky to come up with one major innovation, these three continue to develop breakthroughs and don't seem to be slowing down any time soon. In fact, they seem to be accelerating their ability to create impressive new products and services.

    However, they are very different organizations, which vary widely in their cultures, practices, products and innovation processes. Each has developed in its own way and found its own path, but managed to come up with a repeatable model that works. Despite these differences, however, looking at them together can help us uncover some common principles of innovation.

    Over a Century of Innovation

    It seems that every generation sees IBM falter. It was caught off guard by the minicomputer revolution in the 1980s, outmaneuvered and then outperformed by companies like Microsoft, Intel and Sun Microsystems in the 90s and then pummeled by cloud technologies more recently. Each time pundits declared the firm a dinosaur, soon to be extinct.

    Yet each time IBM has emerged once again and, today, it remains profitable and on the cutting edge. It has pioneered technologies of the future, such as artificial intelligence, blockchain, quantum computing and neuromorphic chips and vies for leadership in each of those areas. Not bad for a company that's been around since Woodrow Wilson was President.

    The secret to IBM's incredible durability is its Research division, which has won more Nobel prizes than most countries. It begins exploring technologies long before they become commercially viable -- or even have a clear application -- and patiently waits while they mature. When they do, the company is usually years ahead of the competition.

    An Integrated Innovation Ecosystem

    In many ways, IBM's mirror image is Google. While IBM is old, Google is young. IBM is deliberate and patient, while Google seems to move at warp speed. IBM focuses on designing systems for enterprises, Google mostly sells finished products to consumers. IBM has long fallen out of fashion, but Google is a tech darling.

    Yet there is a growing rivalry between the two companies in fundamental technologies, especially quantum computing and artificial intelligence. That's incredibly impressive when you think about it. IBM has been building scientific expertise for decades, while Google has built a world class research effort in just about ten years.

    The secret to Google's success is how it integrates a number of strategies into a single coherent ecosystem. The firm invites dozens of top researchers to take a sabbatical at the company every year, which injects top-notch scientific talent. Its 20% time policy pulls in ideas from all over the company and its corporate venture capital operation does the same for the startup community. When an idea has promise, it can be incubated at the company's "X" division.

    For example, the Google Brain project started when Andrew Ng, a star artificial intelligence researcher, came to the company on sabbatical. While there, he began working on a 20% time project with Googlers Jeff Dean and Greg Corrado and eventually they moved to the "X" division. In 2012 it moved back to the mothership and now acts as its own unit.

    A Unique Culture Focused on the Customer

    While IBM has mastered innovating fundamental technologies, Amazon excels at innovating business models. Starting out as an online book retailer, it quickly moved into other product categories. More recently, it pioneered cloud computing, smart speakers and is now moving into healthcare.

    What makes Amazon unique is the culture it has built around the customer. While many are happy to pay lip service to the concept, Amazon has built a number of practices that force its people to take the customer's point of view even before a product begins development. That focus then permeates the rest of the process.

    At the heart of how Amazon innovates is its six-page memo, which kicks off everything the company does. Executives must write a press release, complete with hypothetical customer reactions to the product launch. That is followed by a series of FAQ's, anticipating questions customers, as well as internal stakeholders, might have.

    Executives at the company have stressed to me how the process forces you to think things through. You can't gloss over problems or hide behind complexity, you actually have to work things out. All of this happens before the first meeting. It's a level of rigor that few other organizations even attempt, much less are able to achieve.

    Avoiding the Cargo Cult

    During World War II, soldiers established bases on remote islands in the Pacific. For many of the indigenous people who lived there, it was their first encounter with manufactured technology. They were amazed by how airplanes would land on improvised strips and bring valuable cargo such as food, tents and manufactured goods.

    When the war ended and the soldiers left, some of the islanders established cargo cults. They would mimic the rituals they saw the soldiers perform, such as marching in formation, waving sticks to guide planes in and lighting torches to illuminate runways at night. Perhaps not surprisingly, none of this attracted any planes to return.

    This all seems more than a little bit silly, of course. Anybody who thinks that performing rituals will make planes appear out of the sky is missing some very basic concepts of aviation. Yet modern executives often make the same mistake, mimicking the rituals of other, more successful firms, without internalizing the culture and practice behind them.

    Make no mistake. Establishing a research division, starting a 20% time program or forcing your employees to write six-page memos will achieve little if they don't align with your own strategy, capabilities and culture. In fact, those things can even be counterproductive, wasting valuable time and effort that could be more productively applied elsewhere.

    The truth is that there is no one true path to innovation. Neither IBM, Google nor Amazon has hit on the "right" way to innovate, but they have found the right way for them. It is how those practices have become so deeply embedded into the fabric of their organizations over time that makes the difference.

    If you want to innovate, you need to find your own path. 


    How to discover a new drug (and why it’s so difficult) | killexams.com real questions and Pass4sure dumps

    Excerpted with permission from The Drug Hunters: The Improbable Quest to Discover New Medicines by Donald R. Kirsch and Ogi Ogas. Copyright 2018 by Arcade Publishing, an imprint of Skyhorse Publishing, Inc.

    After spending my entire career searching for new medicines, I’ve learned that the only sure thing in the drug hunting business is that you almost never end up with the exact drug you started stalking. The vast majority of my colleagues, all educated at top-flight research universities and working at posh laboratories festooned with high-tech gear, have spent their entire careers groping through the labyrinth of bio-active molecules without ever finding a new compound that safely and effectively improves human health.

    The professor who trained me in pharmacology, an MD, once told me that 95 percent of the time a patient visits a physician he will not actually be helped by the doctor. In most cases, either the patient’s body will heal itself without needing the doctor’s intervention or the disease will be untreatable, rendering the physician powerless. In his view, the physician has the ability to make a meaningful difference to his patients only 5 percent of the time. While that may seem low, those are fantastic odds compared to the ones faced by the drug hunter.

    Only about 5 percent of a scientist’s ideas for a drug discovery project get funded by management. Of these, only 2 percent end up producing an FDA-approved medicine. That means a drug hunting scientist can only expect to make a difference about one tenth of 1 percent of the time. Finding new drugs is so challenging, in fact, that it has led to a crisis in the pharmaceutical industry. Big Pharma companies are becoming increasingly frustrated with the massive research expenditures necessary to come up with new drugs—an average of about $1.5 billion and fourteen years for each FDA-approved drug—and the exasperating fact that the vast majority of their endeavors don’t produce a usable drug. Executives at Pfizer recently told me they are thinking about getting out of the drug-discovery industry entirely. Instead, they want to be in the drug acquisition industry: they would prefer just to buy drugs that other people have invented. Think about that. Finding new drugs is so formidable that one of the oldest, most talented, and wealthiest drug makers—the largest drug maker in the world, in fact—would rather let other people deal with the problem.

    So why is the “degree of difficulty” of finding new drugs so much greater than, say, landing a man on the moon or designing an atomic bomb? The moon shot and the Manhattan Project employed well-established scientific equations, engineering principles, and mathematical formulas. They were formidable and grueling endeavors, to be sure, but at least the researchers possessed clear scientific road maps and mathematical compasses to guide them. The moon shot engineers knew with certainty the distance from the Earth to the moon, and how much fuel was needed to get there. The Manhattan Project scientists knew that matter could be turned into city-obliterating energy according to E=mc2.

    In contrast, the core challenge of designing a new drug — the trial-and-error screening of immense numbers of candidate compounds — is a task not guided by any known equations or formulas. While an engineer knows if his bridge will bear weight before he ever lays a girder down, a drug hunter has no clear idea how a particular drug will work until a human subject actually ingests it.

    In the mid-nineties, chemists at Ciba-Geigy (now a part of Novartis) calculated the total number of possible drug compounds in our universe: 3 x 1062. When it comes to characterizing the size of a number, some numbers are big, some are enormous, and some are so incomprehensibly, inconceivably large that they might as well be infinity. The number 3 x 1062 falls into that third category. If you were able to test one thousand compounds every second to see if any of them could serve as an effective remedy for a particular malady—say, breast cancer—by the time our sun burned out you would still have not made a measurable dent in the total number of breast cancer-fighting drug possibilities.

    There is a story by the blind Argentinean author Jorge Luis Borges that I think perfectly captures the central challenge of drug hunting. In “The Library of Babel,” Borges imagines that the universe is a library consisting of an infinite number of hexagonal rooms that extend forever in every direction. Each room is filled with books. Each book contains a random arrangement of letters, and no two books are the same. Once in a while, purely by chance, a book contains an entire readable sentence, such as “The gold is in the mountain.” But, as Borges puts it, “For every rational line or forthright statement there are leagues of senseless cacophony, verbal nonsense, and incoherency.”

    Nevertheless, the library must contain books that, purely by chance, are filled with legible life-changing wisdom. Such books are known as “Vindications.” In Borges’s fantasy, solitary searchers known as librarians wander endlessly through the library, hoping to find these Vindications. Most librarians wander through the endless hexagons in vain, spending their life coming across nothing but nonsense. But Borges notes that there are librarians who, through good fortune or sustained force of will, have managed to discover a Vindication.

    Similarly, every possible drug is contained somewhere in the vast theoretical library of chemical compounds. There is a molecular configuration that will safely destroy ovarian cancer, another that will halt the corrosive advance of Alzheimer’s, another that will cure AIDS—or maybe they do not exist at all. There is no way to know for sure. Modern drug hunters are like Borges’s Babelian librarians, forever questing for life-changing compounds and always suppressing their secret fear that the vindicating medicines may never be found.

    The problem, ultimately, is the human body. Our physiological activity is not a closed, well-defined system like rocket propulsion or nuclear fission. It is an open and unfathomably arcane molecular system with innumerable undefined relationships among its components, rendered even more abstruse by the fact that each person’s body has their own idiosyncratic structure and dynamics. We only understand a tiny fraction of these physiological relationships and have not yet deciphered how most of our body’s basic molecular components actually work. Complicating matters still further is the fact that each individual has her own idiosyncratic genetic and physiological architecture, so that each person’s body operates slightly (or extremely) differently. Even more daunting, despite tremendous advances in our understanding of cells and tissues and organs, we simply cannot precisely predict in advance how a given chemical compound will interact with a given molecule in a living body. In fact, it is impossible to know with certainty if a particular disease possesses what pharmacologists call a “druggable protein” or a “druggable target”—some specific protein associated with a pathology that can be influenced by a chemical agent.

    Designing an effective drug requires two things: the right compound (the drug) and the right target (the druggable protein). The drug is like a key that turns the protein lock to start the ignition on a physiological engine. If a scientist wants to intentionally influence a person’s health in a specific way—to reduce depression, relieve itching, treat food poisoning, or produce any other health benefit—she must first identify a target protein that influences the relevant physiological processes in the human body or that, conversely, interferes with the physiological processes of a pathogen.

    For example, Lipitor acts upon HMG-CoA reductase, the protein controlling the rate of the body’s synthesis of cholesterol. Penicillin, in contrast, shuts down peptidoglycan transpeptidase, a protein required to synthesize the (essential) cell wall of a bacterium. But finding the drug key that will turn a protein lock . . . As Hamlet would say: Ay, There’s the rub! This is the daunting challenge for the drug hunter. Despite the humbling odds, some drug hunters, such as Suren Sehgal, through unwavering resolution or outrageous fortune, through individual genius or far-flung collaborations, have stumbled upon their Vindications.

    The term drug hunters have bestowed upon the process of systematically searching through a library of compounds is screening. The prehistoric screening method consisted of snatching every new berry or leaf you came across and snorting it, smearing it, or swallowing it. After unknowable eons of our ancestors randomly sampling the natural landscape, in 1847 the first drug was discovered using a reasonably scientific method of screening. At the time, physicians were using ether as a surgical anesthetic, prompting them to reason that there could be other chemical compounds similar to ether that might work even better. Ether had a few obvious shortcomings—it irritated patients’ lungs and had an unfortunate tendency to explode—so physicians knew there would great clinical value for a new anesthetic without these issues.

    Since ether was a volatile organic liquid, the Scottish physician James Young Simpson and two of his colleagues decided to test every volatile organic liquid they could get their hands on. Their screening process was simple: they opened a bottle of a given test liquid and inhaled its vapors. If nothing happened, they labeled the sample inactive. If they woke up on the floor, they labeled the sample active.

    This screening protocol, of course, would never meet contemporary standards for laboratory safety. Benzene, for instance, is a volatile organic liquid that was widely available at the time and was almost certainly one of the compounds that Simpson screened. We now know that benzene is carcinogenic, and inhaling its vapors can cause long-term damage to your ovaries or testes.

    Despite the recklessness of their screening method, on the evening of November 4, 1847, Dr. Simpson and his colleagues tested chloroform. When the three men inhaled the chemical it produced a mood of cheer and good humor—followed by collapse and unconsciousness. When they awoke hours later, Simpson knew they had identified an active sample.

    Hoping to confirm their findings, Simpson insisted that his niece, Miss Petrie, inhale the chloroform while he watched. The girl blacked out. It is fortunate she woke again, since we now know that chloroform is a powerful cardiovascular depressant, producing a high incidence of death when used as a surgical anesthetic. Despite these dangers, by sniffing chemical after chemical in his living room, Simpson had discovered one of the blockbuster drugs of the nineteenth century—a pharmaceutical origin story unlikely to be duplicated today. But you never know. In the 1980s, I tried to find new drugs in the back of a Volkswagen microbus.

    If you are thinking that I must have been indulging in tie-dyed psychedelic experimentation—after all, why else would anyone be diverting himself with unknown drugs in the back of a lime-green VW bus?—you would be wrong. One of my first paid jobs was working as a drug hunter in an antibiotics discovery group. A common method for searching for new antibiotics is to screen microorganisms living in the soil. I always kept an eye out for new kinds of soil that might hide a pharmaceutical payoff—and a commercial payoff. I was literally looking for pay dirt.

    One weekend, I volunteered to travel to the Delmarva Peninsula to screen soil samples from the Chesapeake Bay side of the peninsula. I took our “mobile laboratory”—the microbus, which we had equipped with a sink and a Bunsen burner. Since my group had recently discovered a new type of antibiotic called monobactams, we christened our mobile laboratory the “Monobacvan.”

    I somehow managed to recruit my wife to come with me with promises of sunbathing on the beach, but then conscripted her into driving the Monobacvan around the tight curves of the rural shoreline as I hunkered down in the back, abruptly ordering her to stop so I could dash out and fill bags full of dirt. During those moments when we were not driving or scooping up the dank, smelly Chesapeake earth, I was diluting the samples and slapping them on Petri plates. My wife was not pleased. The weekend was a bust for both of us, since when I got back to the lab on Monday and we tested my samples, each one turned out to be inactive. My wife informed me that if I did not want my marriage labeled inactive, our next road trip needed much more sunbathing and absolutely no more screening.

    When people learn that I am a drug hunter they usually ask me at least one of the following three questions—usually expressed with some well-founded cynicism:

    Why are my drugs so expensive?

    Why do my drugs have such unpleasant side effects?

    Why is there no medicine for the malady that afflicts me or someone I love?

    The truth of the matter is that the answers to all three are tied to the fact that drug hunting—at least, thus far—is dismayingly difficult because every contemporary method of drug development relies, at some crucial juncture, on trial-and-error screening, just as it did when Neanderthals roamed the wilds. We still do not possess adequate knowledge of human biology to provide us with theories and principles that could rationally guide us to the salubrious molecules we so fiercely desire.

    # # #

    Excerpted with permission from The Drug Hunters: The Improbable Quest to Discover New Medicines by Donald R. Kirsch and Ogi Ogas.


    Bear Archery Renews Focus and Breaks Ground with 2019 Lineup | killexams.com real questions and Pass4sure dumps

    For 85 years, Bear Archery has committed to continuing what their creator starter. Founded by the iconic father of modern archery, Fred Bear believed in making archery accessible to all people without sacrificing quality. In 2019, the Bear Archery team has a reinvigorated spirit and believe they are launching the best product they’ve ever had after refocusing to listen to their customers.

    “While holding true to our founding principles of yesterday,” says Dave Parker, Bear Archery General Manager, “We have renewed our focus on the future and are bringing to market the best product we’ve ever had because we’ve listened to the requirements of our customers and the needs of the consumer.”

    Bear Archery is striving to bring the most dependable and reliable bows to market after meticulously manufacturing and assembling every component to ensure your success. The company offers compound bows including a main line and Legend Series, crossbows, traditional bows, youth, and recreational bows.

    “We hear our customers say all the time, ‘my first bow was a Bear,’” says Parker. “We are committed to making sure your first bow is a Bear, and your next bow is a Bear, and your last bow is a Bear.”

    To stand by that commitment, Bear Archery has created bows that continue to improve the shooting experience across the archery industry. This year’s main line of bows feature incredible adjustability and customizability for the price paid. The lineup of bows can be found at your local dealer and major retailers across the country.

    Headlining the main line roster is the all-new 2019 Divergent bow. Designed with the whitetail hunter in mind, the Divergent offers amazing performance in a short 28” axle-to-axle bow, weighs only 3.9lbs., and will not break your wallet. With speeds of 338 feet per second, the Divergent’s compact platform and hybrid cams give shootability a whole new meaning.

    “We continually push the limits of our risers, limbs, and cams, and the Divergent represents optimization of each of those systems,” says Timmy Langley, Bear Archery Engineer. “It is a small bow that packs a huge punch. It has features that compare with bows that cost hundreds more and we are all excited to get it out in the hands of hunters everywhere.”

    The Divergent offers $1,100 worth of performance and will be offered at a retail price of $699.99. This bow is available in six different finishes including RealTree® Edge™, Veil® Stoke™, One Nation® Midnight, Kryptek® Highlander, True Timber® Kanati™, and Iron.

    In addition to the Divergent, the main line also features three new bows – the Revival, Species LD, and Limitless. The Revival is a high-performance target bow built for accuracy and comfort with an easy draw for consistency and repetition.

    Faithful favorites from last year’s main line return including the Approach, a 32” axle-to-axle single cam system with features of a bow that would cost hundreds more, and the Cruzer G2, a maximum-versatility bow engineered for all ages and skill levels.

    The 2019 Legend Series, an exclusive dealer-only line of ultra-competitive compound bows, introduces two new bows, the Kuma 30 and Perception. The Kuma 30 delivers the same incredible performance of the Kuma with less weight and smaller axle-to-axle. As this year’s flagship, the Kuma 30 brings both speed and comfort in a smaller and lighter package. The Kuma 30 is available in four finishes – RealTree® Edge™, Veil® Stoke™, One Nation® Midnight, and Iron.

    “The new Kuma 30 was made possible due to our innovative roller hinge guard and advanced riser design,” says Langley. “Our roller hinge guard system is truly unique as it consistently reduces the lateral load from the cables each and every shot.”

    The Kuma 30 was inspired by the extremely popular Kuma bow, a hybrid cam bow that shoots 345 feet per second and offers a smooth draw and high-level of forgiveness. To round out the Kuma family is the Kuma LD, which has the same trusted Kuma performance in a longer 27” to 32” draw length range.

    “The Kuma is a very balanced bow the Kuma 30 takes that one step further making it shorter, lighter more moveable,” says Ryan Shutts, Bear Archery Director of Product Management.

    Also new to the Legend Series this year is the Perception, a bow that promises you’ll never look at Bear Archery the same way again. The Perception is the first bow of its kind, a shoot-through engineered with all the performance of a target shoot-through in a small hunting bow package. This limited edition bow weighs only 4.3 lbs. and shoots 350 feet per second.

    “It’s arguably the finest, most technical bow that Bear has ever produced and we know it’s going to get people’s attention,” says Parker. “Bear’s ability to produce high end bows has been somewhat underestimated by the archery community due to its success at the lower end of the price spectrum. That’s why we named it the Perception as it will change how people view Bear bows in the future.”

    Bear Archery also is launching reinvigorating and exciting new products to their Bear X Crossbow line. Engineered for top-of-the-line speed, extreme accuracy, and dependability, these incredible weapons are perfect for any new to experienced hunter looking to spend more time in the woods.

    Two new Bear X crossbows are the Saga 370 LS and Saga 370, ultra-fast crossbows that are dependable, trustworthy enough for the whole family to use, and sleek, lethal weapons. Shooting at 370 feet per second, these crossbows weigh 7.5 lbs. and offers 175 lb. draw weight while measuring 18” uncocked and 14” cocked.

    The Saga 370 LS is a dealer-only bow with upgraded accessories for added comfort including an illuminated scope, quiver, neoprene sling, three carbon bolts, cocking rope, rail lube/string wax.

    Another new addition to the Bear X lineup is the Vanish. This is a dependable, safe, accurate, and fast shooting bow at 370 feet per second with a draw weight of 190 lbs. The Vanish comes ready to shoot with scope, quiver, three carbon bolts, cocking rope, rail lube/string wax.

    “It is an exciting time at Bear! We have been fortunate to have added some great talent to our team this year,” says Parker. “Ryan Shutts, Chris Parrish, Billy Holzhauser and Jack Borcherding have joined team Bear and have brought with them not only a wealth of experience, but a lot of energy and enthusiasm as well!”



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